Neurolymphomatosis Associated with Erythrodermic Mycosis Fungoides

Abstract

© 2014 The Authors. doi: 10.2340/00015555-1684 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Infiltration of the peripheral nervous system by neoplastic cells including non-Hodgikin’s lymphoma is termed neurolymphomatosis (NL). Typical manifestations of NL include peripheral or cranial nerve neuropathy (1). Diagnosis of NL is difficult and requires nerve biopsy, and may be delayed for months or years after the onset of symptoms. Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL), and is characterized by a prolonged clinical course that progresses over years through patch, plaque, and tumour stages. In MF, skin lesions become confluent and finally develop into erythroderma without blood involvement, termed erythrodermic MF (2). We report here an unusual case of NL associated with erythrodermic MF.