Abstract
Prospects for the prevention of postherpetic neuralgia in herpes zoster patients. (University of Rochester School of Medicine and Dentistry, Rochester, NY) Clin J Pain 2000;16:S90–100.This review discussed the results of recent studies that have identified risk factors for the development of postherpetic neuralgia (PHN) and have implicated several peripheral and central mechanisms in its pathophysiology. These risk factors and mechanisms of PHN provide a basis for hypothesizing that combining antiviral therapy with analgesic treatment beginning as soon as possible after the onset of herpes zoster would reduce the risk of PHN beyond that achieved by antiviral therapy alone. Conclude this treatment approach would be expected to reduce the risk of PHN in herpes zoster patients by attenuating acute pain and thereby preventing the initiation of central mechanisms of chronic pain.
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