Abstract
BackgroundDepression and cognitive impairment (CI) are important non-motor symptoms in Parkinson’s Disease (PD) and related syndromes, but it is not clear how well they are recognised in daily practice. We have studied the diagnostic performance of experienced neurologists on the topics depression and cognitive impairment during a routine encounter with a patient with recent-onset parkinsonian symptoms.MethodsTwo experienced neurologists took the history and examined 104 patients with a recent-onset parkinsonian disorder, and assessed the presence of depression and cognitive impairment. On the same day, all patients underwent a Hamilton Depression Rating Scale test, and a Scales for Outcomes in Parkinson’s Disease-Cognition-test (SCOPA-COG).ResultsThe sensitivity of the neurologists for the topic depression was poor: 33.3%. However, the specificity varied from 90.8 to 94.7%. The patients’ sensitivity was higher, although the specificity was lower. On the topic CI, the sensitivity of the neurologists was again low, in a range from 30.4 up to 34.8%: however the specificity was high, with 92.9%. The patients’ sensitivity and specificity were both lower, compared to the number of the neurologists.ConclusionsNeurologists’ intuition and clinical judgment alone are not accurate for detection of depression or cognitive impairment in patients with recent-onset parkinsonian symptoms because of low sensitivity despite of high specificity.Trial registration(ITRSCC)NCT0036819.
Highlights
Depression and cognitive impairment (CI) are important non-motor symptoms in Parkinson’s Disease (PD) and related syndromes, but it is not clear how well they are recognised in daily practice
Non-motor symptoms in PD tend to be underdiagnosed compared to motor problems, which seems logical as the latter are the primary expertise of neurologists
These consultations are often too short to conduct a formal validated test for depression and/or CI. We studied this implicit diagnostic process to assess its accuracy in a consecutive series of patients referred for analysis of a parkinsonian disorder of very recent onset
Summary
Depression and cognitive impairment (CI) are important non-motor symptoms in Parkinson’s Disease (PD) and related syndromes, but it is not clear how well they are recognised in daily practice. Depression and cognitive impairment (CI) are increasingly appreciated as important non-motor symptoms in patients with Parkinson’s disease (PD) and related syndromes [1,2,3,4,5,6,7,8,9,10,11]. These consultations are often too short to conduct a formal validated test for depression and/or CI We studied this implicit diagnostic process to assess its accuracy in a consecutive series of patients referred for analysis of a parkinsonian disorder of very recent onset.
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