Abstract

BackgroundTherapeutic intervention has recently been actively performed for metastatic spine tumor even though spinal cord paralysis is not clearly observed, but there has been no report in which the degree of spinal cord compression by tumor was taken into consideration for the paralysis-preventing effect of treatment. Thus, we investigated the neurological outcome after treatment of patients with spinal cord compression in a state of impending paralysis.MethodsA retrospective cohort study. The subjects were 88 patients with epidural spinal cord compression (ESCC) scale 1b or severer compression with American Spinal Injury Association (ASIA) E spinal metastasis. The neurological outcome after the therapeutic intervention was investigated at regular intervals until death. The therapeutic intervention was posterior decompression and stabilization in 18 patients, stabilization without posterior decompression in 15, and radiotherapy in 55 patients (3 groups).ResultsThe ASIA aggravation group was comprised of 15 patients, and the severity of paralysis was ASIA A in 3, B in 3, C in 6, and D in 3. Paralysis appeared in 16.7% in the posterior decompression and stabilization group, 13.3% in the posterior stabilization without decompression group, and 18.8% in the radiotherapy group. In the transverse view, the incidence was high in cases with advancement to the intervertebral foramen and circumferential-type advancement, and paralysis developed in more than 20% of ESCC 1c or severer cases. Factors influencing neurological aggravation were investigated, but there was no significant factor.ConclusionIn ESCC 1b or severer cases with ASIA E spinal metastasis, paralysis aggravated after therapeutic intervention in 16.7% in the posterior decompression and stabilization group, 13.3% in the stabilization without decompression group, and 16.7% in the radiotherapy group. There was no significant factor influencing the development of paralysis.

Highlights

  • Therapeutic intervention has recently been actively performed for metastatic spine tumor even though spinal cord paralysis is not clearly observed, but there has been no report in which the degree of spinal cord compression by tumor was taken into consideration for the paralysis-preventing effect of treatment

  • The subjects were 88 metastatic spine cancer patients with epidural spinal cord compression (ESCC) scale [8] 1b or severer (Fig. 1) spinal cord compression at American Spinal Injury Association (ASIA) [9] E representing the absence of spinal cord paralysis who received therapeutic intervention

  • Patients with manifestation of paralysis The ASIA aggravation group after therapeutic intervention was comprised of 15 patients, and the grade was A in 3, B in 3, C in 6, and D in 3

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Summary

Introduction

Therapeutic intervention has recently been actively performed for metastatic spine tumor even though spinal cord paralysis is not clearly observed, but there has been no report in which the degree of spinal cord compression by tumor was taken into consideration for the paralysis-preventing effect of treatment. We investigated the neurological outcome after treatment of patients with spinal cord compression in a state of impending paralysis. No study reported whether therapeutic intervention can truly prevent paralysis in patients with a spinal cord-compressing lesion in a state of impending spinal cord paralysis. The degree of spinal cord compression was quantitatively evaluated and the neurological outcome of therapeutic intervention in a state in which spinal cord compression is impending but paralysis has not developed was examined

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