Abstract
Dengue fever is a highly endemic mosquito-borne viral infection with a wide range of neurological manifestations including encephalitis, neuromuscular and neuro-ophthalmic involvement. To explore the pleiotropic effects of dengue virus infection on the nervous system. Effect of the dengue virus on nervous system is pleiotropic. Direct central nervous system invasion by dengue virus is implicated in encephalitis whereas immune mediated release of cytokines may involve peripheral nerve constituents (myelin/axon), muscle fibres leading to myositis, and damage omnipause cells in the brainstem causing ocular flutter. Five patients of serologically confirmed Dengue fever (NS1 Antigen and Immunoglobulin M antibody positive) were included, who presented with the following uncommon neurological manifestations. Recently emerging evidence of neurotropism and neurovirulence by dengue virus emphasizes the need for neurologists to look for these associations while dealing with dengue infection. It also emphasizes the need for specific immunomodulation in addition to supportive measures for causing neurological recovery.
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