Neurological diseases: A perspective genetic approach & dietary intervention

Abstract

Neurological diseases account for a large and increasing health burden worldwide and most vexing afflictions known to mankind. This is since neurological problems are often terrible to patients and their families because the great majority of neurological and neurodegenerative conditions lack effective treatments. There is a plethora of neurological conditions such as Parkinson's, Huntington’s, and Alzheimer’s disease etc. To estimate the rising neurological burden due to genetic or non-genetic (Environmental) factors, DALYs (Disability-Adjusted Life Years) are an essential indicator for estimating the worldwide burden. A systematic and comprehensive data analysis of neurological diseases within the Indian population has warranted that in India prevalence and incidence of neurological diseases is doubled from 4.0% (95 percent UI 3.2-5.0) in 1990 to 8.2% (6.6%-10.2%) in 2019. Several variables contribute to the onset and progression of neurological diseases, including oxidative stress, inflammation, metal imbalances, microbiome, as well as genetic and nutritional factors. Therefore urgently needed to develop new and more effective genetic and therapeutic strategies to combat these devastating diseases. This review demonstrated the increasing global public health importance of neurodegenerative diseases with the help of a new era of omics, influence of dietary intervention, adequate dietary choices as part of a continuation of healthy lifestyle choices, genetic testing, interpretation of genetic testing results, and genetic counseling may help to reduce the risk and may help to decrease the burden of neurological problems.