Neurological Deficit Methodical Approaches to Experimental Study

Abstract

Freasibility of studying pathology of the brain in the experiment leeds to the need for adequate ways to assess the neurological deficit that occurs in animals, including sensorimotor and behavioral disorders, as well as disorders of higher nervous activity (memory, gnosis, praxis, emotional behavior, etc.). The rat is one of the adequate objects of experimental research to study brain disorders in various pathologies. The review summarizes the literature data on possible ways to evaluate sensory-motor reflexes, learning ability and memory in experimental animals at different ages. In the early postnatal period, reflexes are evaluated: "flipping on the plane", "negative geotaxis", "avoidance of breakage", "acoustic stimulus response", "olfactory reaction" and "muscle strength". To study the degree of neurological and behavioral disorders in adult animals, a number of methods can be used: the Bederson test, the test for evaluating modified indicators of the depth of neurological deficit, the Garcia test, the angular test, the paw pulling test, the "open field" test.