Abstract
BackgroundCOVID-19 infection can show various manifestation, including neurologic manifestations, such as anosmia, ageusia, or dysgeusia, and causes the neurologic disorder such as stroke, Guillain-Barre syndrome, encephalopathy, and many more.AimTo briefly review neurologic manifestation in COVID-19 infection in the Asia region (South East Asia and the Western Pacific Region).Material and methodsThis review uses the PRISMA statement and checklist. The source for reviewed article was performed in PubMed that were published between December 2019 to September 2020 with the latest 1 year of publication. Study titles were first screened, then reviewed by title and abstract and then the last review, we tested full text and applied eligibility criteria.ResultsWe found a total of 9 retrieved articles from the electronic database. Among these 9 articles, 5 of them are case report, 1 case series, 1 prospective multi-center cohort study, 1 retrospective multi-center study, and 1 retrospective observational study. All articles reported confirmed COVID-19, confirmation by positive swab test using the real-time RT-PCR method, with neurologic manifestations, disorder, or syndrome on presentation or found during hospital stay. In case of neurologic disorder or syndrome, the studies reported encephalitis and ADEM, acute cerebrovascular disease, acute symptomatic seizure, and Guillain-Barré syndrome with acute cerebrovascular disease as the most common neurologic disorder associated with COVID-19 infection, followed by encephalitis.ConclusionCOVID-19 also affects the brain, which may result in a global or focal neurologic manifestation. Healthcare provider treating patient with COVID-19 infection should also be aware of neurologic manifestation associated with COVID-19 infection to improve patient’s outcome.Guillain-Barre syndrome, encephalopathy, and many more. This review will briefly review neurologic manifestation in COVID-19 infection in the Asian region (South East Asia and the Western Pacific Region. A total of 9 retrieved articles from the electronic database reported confirmed COVID-19, confirmation by RT-PCR method, with neurologic manifestation, disorder, or syndrome on presentation or found during hospital stay. Healthcare provider treating patient with COVID-19 infection should also be aware of neurologic manifestation associated with COVID-19 infection to improve patient’s outcome.
Highlights
COVID-19 or coronavirus disease 2019 is viral infection caused by coronavirus
Healthcare provider treating patient with COVID-19 infection should be aware of neurologic manifestation associated with COVID-19 infection to improve patient’s outcome
Healthcare provider treating patient with COVID-19 infection should be aware of neurologic manifestation associated with COVID19 infection to improve patient’s outcome
Summary
COVID-19 or coronavirus disease 2019 is viral infection caused by coronavirus. Based on its phylogenetic test, it is included in the same subgenus as coronavirus, which caused the SARS outbreak in 2002–2004, Sarbecoronavirus. This disease started from pneumonia of unknown etiology in Wuhan, China, in December 2019 and has spread worldwide since and stated as a pandemic in most countries in the world, including Asian countries [1]. Western Pacific region consists of other Asian countries, the region with the lowest confirmed case and death with 600,891 (2%) and 13.129 (1%) death [2]. COVID-19 infection can show various manifestation, including neurologic manifestations, such as anosmia, ageusia, or dysgeusia, and causes the neurologic disorder such as stroke, Guillain-Barre syndrome, encephalopathy, and many more
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