Abstract

That persons with malaria often show symptoms suggesting involvement of nervous system has been recognized for many years. However, recently there has been an increase of interest in regard to these neurologic manifestations associated with malarial infections. Harvey, 1 in 1944, reported several cases of malaria with associated neuritis. Fitz-Hugh and associates, 2 in 1945, presented a large series of cases of malaria in which there was cerebral involvement. McGinn and Carmody, 3 in 1944, observed that at a base hospital, cerebral symptoms have been most serious and frequent complication in patients suffering from malaria. Kean and Smith 4 reviewed 100 cases of estivoautumnal malaria with autopsy and concluded that the plugging of cerebral capillaries did not appear to be closely related to occurrence of symptoms of cerebral malaria. One of us (R. H. R.), 5 in 1944, reviewed lesions in brain occurring with

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