Abstract
Achieving an appropriate balance between excitatory and inhibitory synapses as the central nervous system is wired up during development is critical for building smoothly flowing information pathways. Neuroligins are postsynaptic adhesion molecules that also play a role in synapse formation. Chih et al. (see the Perspective by Hussain and Sheng) have analyzed knockdown mutants of several neuroligin isoforms and found that various neuroligins have overlapping, but not identical, functions. Disruption of neuroligin function leads to a loss of excitatory synapses and results in a functional imbalance of excitatory and inhibitory transmission in the rodent hippocampus. B. Chih, H. Engelman, P. Scheiffele, Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 , 1324-1328 (2005). [Abstract] [Full Text] N. K. Hussain, M. Sheng, Making synapses: A balancing act. Science 307 , 1207-1208 (2005). [Summary] [Full Text]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.