Abstract
Many studies have investigated the relationship between medication and P300 abnormalities in schizophrenics; however, the effects of neuroleptic medication on the P300 generation were still unclear. Event-related potentials (ERPs) were recorded from nine drug-free patients with schizophrenia including five neuroleptic naives; their ERPs were re-recorded after about 3 months of neuroleptic medication. Sixteen channel ERP data were obtained using auditory oddball paradigms. There was no difference in the mean P300 peak latency and amplitude before and after the treatment. On the other hand, the mean P300 latency at the point of maximal GFP was shorter. Latency adjusted grand average at the point of maximal GFP of each individual P300 component. Then, the current source density of the P300 was computed using low-resolution electromagnetic tomography (LORETA) analysis. LORETA revealed that the cortical current density of P300 components increased after treatment, especially in the front–temporal areas. These results suggest that neuroleptic medication changes the P300 generators in schizophrenia.
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