Abstract
Obesity is the major risk factor for many chronic diseases such as diabetes, hypertension, cardiovascular diseases, and cancer. Obesity has a negative impact on the immune systems. Obesity is associated with chronic low-grade inflammation and altered immune functions. The regulation of body weight is by the interplay of many neuronal circuitries in the brain that control the food intake and energy expenditure. There is a link between the central nervous system (CNS) and immune system. Therefore, in the present review article, we have discussed the immunomodulation in obesity and its interactions with the CNS.
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