Abstract
AbstractBipolar disorder is a serious psychiatric disorder in youth associated with significant long-term morbidity and mortality. Yet, the etiopathogenesis of this illness is poorly understood. Recent advances in brain imaging have helped clarify the brain changes associated with this disorder at an early age. Specifically, bipolar disorder appears to involve abnormalities in discrete brain networks that may include prefrontal, subcortical, and cerebellar regions. The expression of the symptoms of bipolar disorder does not appear to result from single, localized brain lesions, but rather are emergent properties of dysfunction of these brain networks. As neuroimaging techniques continue to advance, the underlying neural basis of bipolar disorder will be clarified.
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