Abstract
When the first suspected cases of neurologic disorders associated with the Zika virus were noticed in Brazil in late 2015, several studies had been conducted to understand the pathophysiology of the disease and its associated complications. In addition to its well-established association with microcephaly in neonates, the Zika virus infection has also been suggested to trigger other severe neurologic complications in adults, such as Guillain-Barré syndrome, radiculomyelitis, and meningoencephalitis. Hence, the Zika virus should be deemed a global threat that can cause devastating neurologic complications among individuals in all age ranges. The aim of this review was to further describe neuroimaging findings of Zika virus infection and associated neurologic complications found in adults.
Highlights
SUMMARY: When the first suspected cases of neurologic disorders associated with the Zika virus were noticed in Brazil in late 2015, several studies had been conducted to understand the pathophysiology of the disease and its associated complications
In an effort to improve diagnostic accuracy, a Brazilian study has shown that cross-reactivity might be overcome by using a Zika virus (ZIKV) immunoglobulin M (IgM) antibody capture enzymelinked immunosorbent assay (ELISA) of both CSF and serum in cases of ZIKVassociated neurologic complications.[17]
The rash might be more promi- and its positivity in the CSF suggests recent intrathecal antibody synnent with ZIKV, whereas dengue fever (DENV) leads to more pronounced thesis and direct CNS penetration of ZIKV.[18,19]
Summary
SUMMARY: When the first suspected cases of neurologic disorders associated with the Zika virus were noticed in Brazil in late 2015, several studies had been conducted to understand the pathophysiology of the disease and its associated complications. Some authors have described a concomitant increase in the incidence of both Guillain-Barresyndrome (GBS) and ZIKV infection.[7,8,9] Association with other neurologic complications in adults has been suggested, including meningoencephalitis,[10] transverse myelitis (TM),[11] and ophthalmologic diseases.[12]
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