Abstract
ObjectivesNeurodevelopmental impairment has become the most important comorbidity in infants with congenital heart disease (CHD). We aimed to (1) investigate the burden of brain lesions in infants with CHD prior...
Highlights
Congenital heart disease (CHD) is the most common congenital defect,[1] affecting ~1% of newborns.[2]
Few infants born with major congenital heart disease (CHD) survived to adulthood,[3] but advances in diagnostic, interventional and surgical techniques over recent decades have led to dramatic increases in survival.[4]
►► Abnormal brain development in CHD is observed in utero, with a derailment of normal growth becoming most pronounced in the third trimester
Summary
Congenital heart disease (CHD) is the most common congenital defect,[1] affecting ~1% of newborns.[2] Historically, few infants born with major CHD survived to adulthood,[3] but advances in diagnostic, interventional and surgical techniques over recent decades have led to dramatic increases in survival.[4] children with CHD remain at risk of neurodevelopmental impairment, characterised by mild cognitive impairment, impaired social and communication skills, inattention and later, deficits in executive function.[5,6,7,8,9,10,11,12]. ►► Neurodevelopmental impairment is a common comorbidity in major congenital heart disease (CHD), affecting up to half of children. It has become clear that neurological insult in CHD begins before surgery, with altered neurological state in the newborn period,[13] population studies
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