Neuroimaging as a Tool to Elucidate Gene-Brain-Behavior Associations in Williams Syndrome

Abstract

Event Abstract Back to Event Neuroimaging as a Tool to Elucidate Gene-Brain-Behavior Associations in Williams Syndrome A. L. Reiss1* and K. F. Berman2 1 Stanford University School of Medicine, Center for Interdisciplinary Brain Sciences Research (CIBSR), United States 2 National Institutes of Health, Section on Integrative Neuroimaging, United States Williams syndrome is an intriguing and enigmatic neurodevelopmental condition that affects motor, sensory, language, cognitive, emotional and social development. Because the genetic risk factors for this condition have been identified, there is now the opportunity to begin to develop a better understanding of how genetic (and environmental) factors affect brain development and function, and how this ultimately translates into strengths and weaknesses in learning and behavior. As a component of the multi-site program project grant based at the Salk Institute, the Stanford Center for Interdisciplinary Brain Sciences Research (CIBSR) has conducted multi-modal brain imaging studies in individuals affected by Williams syndrome for over 10 years. In the context of increased knowledge of the cognitive-behavioral phenotype associated with this condition as well as molecular genetic pathways, this neuroimaging research has begun to contribute to a better understanding of brain mechanisms in this condition. This presentation will provide an overview of the progression of neuroimaging studies and results from the Stanford CIBSR, with an emphasis on how more recent studies have built upon previous research findings. I also will review how our present knowledge of brain structure and function in Williams syndrome is contributing to a more cohesive, integrated understanding of learning and behavioral function in affected individuals, as well as the generation of new questions for future research. Finally, I will present information pertaining to how neuroimaging research can help inform and facilitate new avenues for treatment of cognitive and behavioral problems associated with Williams syndrome. Conference: 12th International Professional Conference on Williams Syndrome, Garden Grove,CA, United States, 13 Jul - 14 Jul, 2008. Presentation Type: Oral Presentation Topic: SESSION 3: Neuroimaging and Brain Functioning in Williams Syndrome Citation: Reiss AL and Berman KF (1900). Neuroimaging as a Tool to Elucidate Gene-Brain-Behavior Associations in Williams Syndrome. Conference Abstract: 12th International Professional Conference on Williams Syndrome. doi: 10.3389/conf.neuro.09.2009.07.008 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 01 Jan 1900; Published Online: 01 Jan 1900. * Correspondence: A. L Reiss, Stanford University School of Medicine, Center for Interdisciplinary Brain Sciences Research (CIBSR), Stanford, CA, United States, areiss1@stanford.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers A. L Reiss K. F Berman Google A. L Reiss K. F Berman Google Scholar A. L Reiss K. F Berman PubMed A. L Reiss K. F Berman Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.