Abstract
The effect of oxytocin (OXT), vasopressin (VP) and a dopamine-receptor antagonist, pimozide (PIM) was investigated on stereotype sniffing behaviour in rats and locomotor hyperactivity in mice induced by a single injection of cocaine. The cocaine-induced sniffing behaviour (CISB) was decreased by subcutaneous (s.c.) and intracerebro-ventricular (i.c.v.) injection of OXT and s.c. PIM but not after s.c. VP. The cocaine-induced motor hyperactivity (CIMH) was attenuated by s.c. injected VP and PIM but not OXT. These results suggest that the dopaminergic neurotransmission may have an important role in mediating the acute behavioural effect of cocaine and the neurohypophyseal hormones can modify these effects.
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