Abstract
Patients with Coarctation of the Aorta (CoA) have reduced life expectancy because they present with cardiovascular complications late after repair such as, recoarctation, hypertension and aneurism formation, [1] while there is evidence of vascular dysfunction [2]. The mechanisms responsible for the late complications in a variety of congenital heart diseases (CHD) have been attributed to a pattern of neurohormonal and immune activation [3,4]. The aim of our study was to evaluate whether immune and neurohormonal activation and vascular dysfunction, which is observed in mixed cohorts of patients with CHD, occur early, in children under 12years old with repaired CoA.
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