Abstract
Morphological changes in neuroglial cells of the central nervous system during aging include astrocytic hypertrophy, myelin alterations, shape changes of microglial cells, and decreased volume of the extracellular space. Age-related changes in neuroglial cells of the peripheral nervous system include myelin alterations, decrease in volume of perineuronal satellite cell sheaths, and increased surface area of sensory ganglion neurons unprotected by the satellite cell envelopment. Some of these changes probably contribute to the behavioral impairment and cognitive decline that often accompany normal aging.
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