Abstract
Neurogenin 3 is important but not essential for pancreatic islet development in humans.
Highlights
To the Editor: Based on the findings that Neurog3-null mice fail to develop pancreatic islets [1] and lack enteroendocrine cells [2], this basic helix-loop-helix transcription factor is considered to be essential for differentiation of endocrine cells both in the pancreas and in the gut [3]
Limited data from human fetuses suggest that transient expression of neurogenin 3 (NEUROG3) in pancreatic progenitor cells from approximately 7 to 8 weeks post conception is followed by beta cell differentiation and immature islet formation by week 12 of fetal development [4, 5]
The patients did not present with neonatal diabetes, suggesting that pancreatic islet development was at least partially spared, they developed diabetes during late childhood
Summary
Neurogenin 3 is important but not essential for pancreatic islet development in humans. Oscar Rubio-Cabezas & Ethel Codner & Sarah E. Received: 2 May 2014 / Accepted: 22 July 2014 / Published online: 14 August 2014 # The Author(s) 2014. This article is published with open access at Springerlink.com.
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