Abstract
The primary respiratory rhythm generator is located in a relatively small area of the lower brainstem and can be defined by the neuronal properties and synaptic interactions within this limited area. The genesis and control of the respiratory motor pattern involve a complex cross-level integration of cellular, network and systems mechanisms. Computational modeling is a powerful method that allows linking experimental data related to different levels of system organization. Therefore, a comprehensive computational model can provide useful insights for understanding the multilevel neural mechanisms involved in generation and control of the respiratory pattern. Our ultimate goal is to develop such a model.
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