Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression

Andrew Geoffrey Bourne Thompson,Amanda J Heslegrave,Henrik Zetterberg,John Collinge,Simon H Mead,Graham S Jackson,Connie Luk

doi:10.1136/jnnp-2017-317793

Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression

Andrew Geoffrey Bourne Thompson, Amanda J Heslegrave + Show 5 more

Open Access

https://doi.org/10.1136/jnnp-2017-317793

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Journal: Journal of Neurology, Neurosurgery & Psychiatry	Publication Date: Feb 27, 2018
Citations: 67	License type: open-access

Affiliation: MRC Prion Unit, University College London, University College London Hospitals NHS Foundation Trust, National Hospital for Neurology and Neurosurgery, UK Dementia Research Institute, Sahlgrenska University Hospital, University of Gothenburg

#Rate Of Disease Progression #Neurofilament Light + Show 8 more

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Abstract

ObjectivesA blood-based biomarker of neuronal damage in sporadic Creutzfeldt-Jakob disease (sCJD) will be extremely valuable for both clinical practice and research aiming to develop effective therapies.MethodsWe used an ultrasensitive immunoassay...

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