Abstract
Pigmentation of the skin and multiple neurofibromas are characteristic of Recklinghausen's disease, but numerous other manifestations are seen. 1 Changes in the bone have been observed in cases of neurofibromatosis. Brooks and Lehman, 2 Castronuovo, 3 Camp, 4 Camp, Adson and Shugrue, 5 Gould, 6 Weiss, 7 Adrian, 8 and Stalmann 9 reported cases with various associated changes in the bone, including scoliosis, abnormality of growth, irregularity of outline, central and subperiosteal cysts, pedunculated subperiosteal tumors and pseudo-arthrosis. Siegmund 10 reported a case of neurofibromatosis with bony cavities of the lumbar and sacral vertebrae lined by herniations of the dura and accompanied by aneurysmal dilatations of vertebral arteries. Ocular changes associated with Recklinghausen's disease are also recorded. Goldstein and Wexler 11 described a case of melanotic tumors of the iris with orbital neurofibromas and called attention to the frequent occurrence of orbital neurofibromatosis accompanied by pigmented nevi of the lids,
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