Abstract
Rationale:We report a rare case of neurofibroma in the form of tarsal conjunctival thickening of the eyelid in patients with neurofibromatosis type 1 (NF1), common ocular complications of which are Lisch nodules, choroidal nodules, and optic nerve glioma.Patient concerns:A 46-year-old female patient was diagnosed with neurofibroma after biopsy and removal of 2 lumbar level intradural masses 15 years ago. She was being monitored without recurrence. When the patient visited our hospital, multiple iris Lisch nodules were found in both her eyes with ill-defined, diffuse thickening in the upper eyelid tarsal conjunctiva of the right eye.Diagnosis:Neurofibroma was diagnosed by incisional biopsy and immunohistochemistry of the tarsal conjunctiva.Interventions:The patient of the present case did not undergo any additional surgical treatment because tarsal conjunctiva thickening caused little functional problem.Outcomes:The patient has only been regularly examined for changes in size of neurofibroma, and there was no change in size over a 12-month period.Lessons:Neurofibroma should be considered as a differential diagnosis if a patient diagnosed with NF1 shows tarsal conjunctiva thickening.
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