Abstract
The relationship between T2 weighted MRI images (T2H) and cognitive functioning in a cohort of 76 children with neurofibromatosis type 1 (NF1) was determined in a study at Children's Hospital at Westmead, University of Sydney, Australia.
Highlights
The relationship between T2 weighted MRI images (T2H) and cognitive functioning in a cohort of 76 children with neurofibromatosis type 1 (NF1) was determined in a study at Children's Hospital at Westmead, University of Sydney, Australia
Discrete lesions were usually located in the basal ganglia and cerebral hemispheres, whereas diffuse lesions involved the thalamus, cerebellum and brainstem
T2H in general were not associated with cognitive dysfunction, specific learning disabilities or ADHD, but patients with discrete thalamic lesions showed lower levels of cognitive functioning than those without lesions or with lesions elsewhere (Full scale IQ 72.8 vs 91.4)
Summary
The relationship between T2 weighted MRI images (T2H) and cognitive functioning in a cohort of 76 children with neurofibromatosis type 1 (NF1) was determined in a study at Children's Hospital at Westmead, University of Sydney, Australia. Discrete lesions were usually located in the basal ganglia and cerebral hemispheres, whereas diffuse lesions involved the thalamus, cerebellum and brainstem. T2H in general were not associated with cognitive dysfunction, specific learning disabilities or ADHD, but patients with discrete thalamic lesions showed lower levels of cognitive functioning than those without lesions or with lesions elsewhere (Full scale IQ 72.8 vs 91.4).
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