Abstract
Neurofibrillary tangles and neuronal degeneration were induced by vincristine and vinblastine sulfate in cultures of fetal rabbit spinal cord and dorsal root ganglia. The formation of neurofibrilary tangles began with a condensation of argentophilic fibrils around the nucleus. The clumped fibrils then increased in thickness forming dense argentophilic masses. The tangles corresponded to bundles of closely packed neurofilaments when observed by electron microscopy. Reversion to an almost normal neurofibrillary pattern occurred following vinblastine sulfate withdrawal, while neurofibrillary tangles persisted after withdrawal of vincristine sulfate.
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