Abstract
ARTICLE Sir, We have read with great interest the McGonigal et al . (2010) article, which addresses the pathogenic role of GD1a antibodies and complement activation for node of Ranvier dysfunction. Nodal injury might explain several electrophysiological features and clinical symptoms in patients with Guillain–Barre syndrome including the sometimes rapid recovery from paralysis. In our opinion, the reported mechanisms by which loss of axonal conduction can occur, may account not only for GD1a, but also for further nodal proteins once patients with Guillain–Barre syndrome develop antibodies against them. We therefore analysed sera from patients with Guillain–Barre syndrome for the presence of autoantibodies against two important nodal targets, neurofascin and …
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