NEUROEPIGENETICS IN METHODOLOGY AND TECHNOLOGICAL PLATFORM OF MENTAL MEDICINE

Abstract

The aim of the article is the conceptual and methodological generalization and systematization of new studies on neuroepigenetics for the development of the technological platform of mental medicine (MM). MM is one of the newest examples of reformatting yesterday's nosocentric boundaries and early pre-nosological forecasting of tomorrow's possible mental ailments. The substantiation for the functional lateralization of mentality (mental asymmetry) as one of the tools of neuroepigenetic coding of identity and behavior is proposed. MM harmoniously combines in its technological platform genetic and epigenetic molecular mechanisms, socio-psychological and clinical-psychopathological, spiritual-moral and religious-integrated tools. This allows MM to practically implement yesterday's "neuroepigenetic fantasies" about editing and formatting the design of the network cascade of genetic and epigenetic identity: molecular - cellular - tissue - organ - organism - personal - social - population. The degree and the vector of dispersion of genomic and epigenomic identity reflect possible resources of evolutionary variability embodied in the registers of mental immunity (MI) and manifested by the mental resilience. MI is a neural network multisystem and multimodal identity interface in its interaction with the internal and external environment. The identified basic functional characteristics of MI are modeled by epigenetic switches or labels, and are embodied in behavioral phenomenology or pathoplastics and pathokinetics of mental disorders. The epidemic increase in the prevalence of mental and psychosomatic disorders is suggested to be called the pandemic of mental immune deficiency (PMID) by the name of the earliest and nonspecific syndrome of mental immune deficiency accumulating initial manifestations of MI dysfunctions transgenerationally. The global predictors of PMID are many of the challenges of the modern world: from the psychic traumatization of childhood to cumulative existential stress. In MM sanogenetic therapy as adaptive modulation of MI triggers cascade self-renewal of personality, clinically manifested by its therapeutic drift (diagnoses-syndromes-symptoms-states). The well-known expression of Nobel Laureate Peter Medawar: "Genetics proposes and epigenetics disposes" should be supplemented with a practically significant mission of MM, which embodies the design models of quality and style, the way and meaning of life in adaptive neuroengineering and self-management of consciousness and health.