Abstract
The plasma thyroid-stimulating hormone response to thyrotropin-releasing hormone in controls and patients with affective disorders has been studied. The results of the investigation do not suggest any abnormality of this response in monopolar or unipolar depressed patients or bipolar patients undergoing a manic phase of their illness. No significant difference in this response could be detected between ‘sporadic depressive disease’ patients and ‘familial pure depressive disease’ patients, and age- and sex-matched controls. The neuroendocrine response was essentially unchanged after treatment by ECT.
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