NEUROENDOCRINE MEASURES OF EDC IMPACT IN BIRDS

Abstract

Event Abstract Back to Event NEUROENDOCRINE MEASURES OF EDC IMPACT IN BIRDS Mary Ann Ottinger1*, Meredith Bohannon1, Tiffany Carro1, Leah Carpenter1 and Karen Dean1 1 University of Maryland, Animal and Avian Sciences/ Division of Research, United States Assessing potential risk associated with exposure to endocrine disrupting chemicals (EDCs) has been difficult in birds due to variations in reproductive strategies, life span, and steroid action in precocial and altricial species. In precocial birds, embryonic exposure to EDCs impacts sexual differentiation of neuroendocrine systems and behavior. Often, detectable non-lethal effects of EDCs diminish as the organism matures so that the long term impact of EDCs may appear relatively innocuous by the time an individual is sexually mature. Few studies have considered lifetime effects of EDC exposure in birds, especially in field populations. Assessing the consequences of EDC exposure in field birds is often to complex mixtures rather than to lone compounds. Our studies have been designed to examine effects of individual EDCs administered to the embryo as well as in a multi-generational dietary study in which birds received low doses of the pesticide, methoxychlor (MXC). We also compared effects of dietary methoxychlor exposure in Japanese quail and northern bobwhite quail to compare effects of dietary exposures (0.5, 5 and 10ppm) that are relatively low. Finally, we have considered the comparative effects of a complex mixture. Our data will be discussed in the context of applicability of toxicological yardsticks, including the Toxic Equivalent (TEQ) and Neurotoxic Equivalent (NEQ) as predictive indices for short and long term outcomes to non-lethal concentrations of EDCs. Other approaches have been developed to address inconsistencies in effects and to incorporate diverse data into the potency estimates. Perhaps it is time to develop a more inclusive estimation method for endocrine and neuroendocrine effects. An Endocrine Disruption Index (EDI) would complement other indices, and focus on endocrine disruption and includes effects beyond those mediated by the aryl hydrocarbon receptor (AhR) for a comparative assessment of non-lethal EDC effects. Acknowledgements Acknowledgements: Research supported by EPA grants # R826134010 (Star Grant) and R-82877801; Battelle contract for EPA-EDSTAC validation studies, NRI #92-37203 and NSF #9817024; MAES, University of Maryland, College Park; and U.S. Fish and Wildlife Service. Keywords: aging and development, Birds, endocrine disrupting chemicals, primate aging, Reproductive Behavior Conference: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology, Ann Arbor, United States, 13 Jul - 16 Jul, 2011. Presentation Type: Invited Symposium Topic: Endocrine disruption Citation: Ottinger M, Bohannon M, Carro T, Carpenter L and Dean K (2011). NEUROENDOCRINE MEASURES OF EDC IMPACT IN BIRDS. Front. Endocrinol. Conference Abstract: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology. doi: 10.3389/conf.fendo.2011.04.00040 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 17 Jul 2011; Published Online: 09 Aug 2011. * Correspondence: Dr. Mary Ann Ottinger, University of Maryland, Animal and Avian Sciences/ Division of Research, College Park, MD, 20742, United States, maotting@umd.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mary Ann Ottinger Meredith Bohannon Tiffany Carro Leah Carpenter Karen Dean Google Mary Ann Ottinger Meredith Bohannon Tiffany Carro Leah Carpenter Karen Dean Google Scholar Mary Ann Ottinger Meredith Bohannon Tiffany Carro Leah Carpenter Karen Dean PubMed Mary Ann Ottinger Meredith Bohannon Tiffany Carro Leah Carpenter Karen Dean Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.