Abstract
Neurodevelopmental Outcome in Very Low Birth Weight Preterm Newborns: The Role of Neonatal Sepsis
Highlights
Today prematurity is still a topical and globally discussed issue: 15 million preterm infants are born every year in the world and about 1 million of them dies because of the complications linked to preterm birth [1]
The results prove the role of sepsis in determining a greater neurocognitive impairment in this category of newborns
In particular the studies in literature confirm that preterm neurodevelopmental outcome has greater problems compared to term infants [3,4], especially for babies born under 32 weeks of gestational age or those with birth weight under 1500 g
Summary
Today prematurity is still a topical and globally discussed issue: 15 million preterm infants are born every year in the world and about 1 million of them dies because of the complications linked to preterm birth [1]. In developed countries the largest part of these newborns survives but, because of the complications due to organs and tissues incomplete maturation, there is a high risk of developing long term disabilities [2]. In particular the studies in literature confirm that preterm neurodevelopmental outcome has greater problems compared to term infants [3,4], especially for babies born under 32 weeks of gestational age or those with birth weight under 1500 g (very low birth weight, VLBW). Sepsis can represent a further risk factor for the development. Neonatal sepsis is an independent risk factor for the development of central nervous system injury, so preterm newborn, who is more exposed to infections, has a higher neurological risk. This research wanted to examine whether and how sepsis could influence preterm newborns’ neurodevelopmental outcome
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