Neurodegenerative Diseases (Alzheimer and Parkinson), but Not Vascular Dementia, Are Negatively Associated to Cancer as Cause of Death in the NEDICES Cohort (P01.086)

Abstract

Objective: To analyze the causes of death in two neurodegenerative disorders: AD, PD, and in vascular dementia (VaD) from the Neurologic Disorders in Central Spain (NEDICES). Background Several mortality studies have demonstrated a negative association among some complex diseases (Alzheimer disease –AD-, Parkinson disease –PD-, Down syndrome and others), and cancer as cause of death. Design/Methods: NEDICES is an elderly population-based cohort that investigated neurological disorders and general health in three areas of Central Spain. The mortality status has been evaluated linking the participants with the National Death Registry (NDR) of Spain from the cohort baseline from 1994 until 31-12-2007. The cause of death analyzed was the official cause of death in the NDR. In several logistic regression analyses the Risk Ratio (RR) of the main causes of death were evaluated in AD, PD and VaD cases, adjusted by age, sex and cultural level. Results: The NEDICES cohort was integrated by 5,278 participants. 2,810 were death during the follow up (range: 0-14.7 years). 306 dementia (207 AD and 44 VaD; 54 other and unknown etiology) and 81 PD cases were detected in the baseline study. The cancer diagnosis as cause of death in the NDR were 10 in AD cases; 10 in PD; 2 in VaD cases, and 674 in the rest of death participants.In the logistic regression analysis the adjusted RR for cancer in AD was 0.3 (CI95% =0.2-0.9); p Conclusions: The NEDICES cohort confirmed previous reports of an inverse relationship among AD and PD and cancer as cause of death. This association was not present in VaD. These findings suggest that this association is biologically motivated for an unknown mechanism. Supported by: Fundacion Mutua Madrilena, FIS 93/0773, and Network Center for Neurodegenerative Diseases Research (CIBERNED). Carlos III Institute, Madrid. Spain. Disclosure: Dr. Bermejo-Pareja has nothing to disclose. Dr. Benito-Leon has nothing to disclose. Dr. Trincado has nothing to disclose. Dr. Vega has nothing to disclose. Dr. Villarejo Galende has nothing to disclose. Dr. Posada Rodriguez has nothing to disclose. Dr. Medrano has nothing to disclose. Dr. Louis has nothing to disclose.