Abstract
Background The subiculum, the main output region of the hippocampus, remains largely preserved in human temporal lobe epilepsy (TLE) and therefore may be importantly involved in the generation of epileptic activity arising from the hippocampal region. Our goal was to characterize histopathological and neurochemical changes in the rat subiculum using the kainic acid (KA) model of TLE and to correlate these alterations with data from EEG-recordings.
Highlights
The subiculum, the main output region of the hippocampus, remains largely preserved in human temporal lobe epilepsy (TLE) and may be importantly involved in the generation of epileptic activity arising from the hippocampal region
Increased expression of neurokinin B (NKB) and NPY mRNA was observed in pyramidal neurons of the subiculum, and fiber labeling for NKB and NPY was increased at late intervals after status epilepticus (SE)
Early degeneration of PV-ir GABAergic basket- and axoaxonic cells may result in decreased inhibition of pyramidal neurons and affects the numbers of spontaneous seizures occurring later
Summary
The subiculum, the main output region of the hippocampus, remains largely preserved in human temporal lobe epilepsy (TLE) and may be importantly involved in the generation of epileptic activity arising from the hippocampal region. Our goal was to characterize histopathological and neurochemical changes in the rat subiculum using the kainic acid (KA) model of TLE and to correlate these alterations with data from EEG-recordings
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