Abstract
The electrical activity of three identified bursting neurons (including one "plateau-generating" neuron) is studied in the brain ofHelix lucorum under conditions of complete isolation. A method for isolating the identified neurons is worked out (mechanical extraction by means of microelectrodes). All three neurons are shown to be endogenous oscillators. In the isolated state in the absence of any stimulation they exhibit spontaneous changes in activity: from an inactive state to nongrouped regular activity, from regular activity to burst activity, and vice versa. It is also found that the burst activity of all three isolated neurons can be regulated (initiated, discontinued, parameters altered) using the same neurochemical agents: serotonin, opioid enkephalins. Burst activity can be generated by the combined action of dopamine and enkephalin and discontinued just with dopamine. The possible significance of the described neurochemical mechanism of regulating burst activity in neurons that are endogenous oscillators is discussed with regard to the generation of the rhythm of various cyclic functions.
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