Abstract
The dynamics of neurochemical rearrangements in neurons in the ventromedial reticular formation of the medulla oblongata in rats during the development of neuropathic pain were investigated. Distinct populations of monoaminergic and NOergic projecting neurons and cells that metabolize agmatine were found in the nucleus. The change in the activity of these neurons during the initiation (week 1) and formation (4 weeks) of neuropathic pain has several phases. Decreased synthesis of catecholamines, increased catabolism of agmatine, and activation of NO synthesis were found in neurons by the end of the first week. At 4 weeks after the surgery, the parameters of the catecholaminergic system returned to the control level, NOergic activity was significantly reduced and the catabolism of agmatine continued to increase. These findings suggest the involvement of bulbar NOergic, mono- and polyaminergic neurotransmitter mechanisms in the initiation and maintenance of neuropathic pain.
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