Abstract
A small but significant percentage of patients that Neuroblastomas (NB) are the most common solid tumour in children under the age of five. The aetiology remains unknown, although it has been associated with several genes, such as MYCN in chromosome 17q and LOH in chromosome 1q. The incidence of the disease is 1/100,000 children. Clinical signs and symptoms vary according to the age of patient, the stage of NB, metastases and the secretion of several metabolic products by the tumour. Ninety per cent of NB produces catecholamines. Diagnosis is usually based on characteristic histological findings. According to the Children’s Study Group (CSG) and the International Neuroblastoma Staging System (INSS) NB has four stages. The therapeutic approach is based on the stage of the disease, while age, stage of disease, histological and biological markers are used to predict prognosis. In conclusion, given that correct treatment and prognosis depend mainly on the stage of NB, we urge great care in the staging of the disease.
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