Abstract
Neuroblastic tumors (NBs) show diverse clinical presentation ranging from a regression, through delayed or arrested maturation, to the metastatic spread. The different biological behavior of NBs seems to be determined by the molecular mechanisms associated with neural crest development. HER receptors family which modulates neurogenesis, is involved in genesis and progression of several types of cancer. HER receptors are commonly expressed in NB tumors and it seems that HER family members play an interrelated and complex role in their biology. It is suggested that HERs are related to the neuroblastic cell differentiation and Schwannian stroma development. Moreover, HER expression is considered a potential prognostic factor. Because new treatment options are still warranted in high risk NBs, HER receptors become an evolving target for novel therapeutic approaches such as tyrosine kinase inhibitors or specific antibodies.
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