Abstract
Dr Friedman offers some interesting neurobiologic speculations regarding some of the findings in our recently published study 1 and suggests potential links to particular neurobehavioral systems. Specifically, the possibility of monitoring speech hesitation and switching pauses may represent an intriguing approach to examine a potential mechanism (at a level of specific neurochemical alteration). Further, some of the neurobehavioral systems described are a focus of interest within one of the research programs conducted at the University of Pittsburgh, Pa, actively investigating serotonergically mediated inhibition of dopamine in a study examining prolactin response to a serotonergic agonist in depressed children and normal controls. 2,3 We are also exploring the possibility that some sleep and mood changes relevant to affective disorders may be mediated by changes in frontal-striatal activation, as reflected by electroencephalographic frontal activity asymmetries. 4,5 However, it appears less clear to our interpretation whether the increased right frontal activity is a
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