Abstract
This review is focused on several psychiatric disorders in which cognitive impairment is a major component of the disease, influencing life quality. There are plenty of data proving that cognitive impairment accompanies and even underlies some psychiatric disorders. In addition, sources provide information on the biological background of cognitive problems associated with mental illness. This scientific review aims to summarize the current knowledge about neurobiological mechanisms of cognitive impairment in people with schizophrenia, depression, mild cognitive impairment and dementia (including Alzheimer’s disease).The review provides data about the prevalence of cognitive impairment in people with mental illness and associated biological markers.
Highlights
Cognitive functions are essential for the normal functioning of every individual, and if they are damaged, daily life is extremely difficult and unproductive
This review focuses on the neurobiological basis of cognitive decline in schizophrenia, depression, mild cognitive impairment (MCI), and dementia, Alzheimer’s disease (AD)
We focused on neurobiological mechanisms and associated markers of cognitive impairment in various mental illnesses, schizophrenia, depression, MCI, and dementia
Summary
Cognitive functions are essential for the normal functioning of every individual, and if they are damaged, daily life is extremely difficult and unproductive. Depressive disorders are accompanied by cognitive impairment in various areas, such as attention, executive functions, memory, and processing speed [29,30]. These impairments often persist even during remission. Individuals with memory distortions (impairment of memory and recognition) and classified as pre-amnestic MCI and no underlying medical conditions that could explain these cognitive impairments (such as cerebrovascular disease, anxiety, stress or depression) have an 8.5-fold increased risk of progression to dementia (mainly AD) compared to those classified as possible-naMCI [46,47]. We focused on neurobiological mechanisms and associated markers of cognitive impairment in various mental illnesses, schizophrenia, depression, MCI, and dementia. Genetic, epigenetic, neurotransmitter, neurotrophic, neuroinflammatory, vascular, and mitochondrial aspects will be discussed
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
