Abstract
The effect of a daily intraperitoneal cadmium administration, of 0.4 mg Cd/kg body weight for 30 days to weaned rats on the content of biogenic amines in different brain regions and behavioral pattern was investigated. Significant decrease in 5‐hydroxytryptamine contents of cerebellum and corpus striatum while an increase in hippocampus was noticed in Cd treated rats. Dopamine was significantly increased in cerebellum and hippocampus whereas it was decreased in corpus striatum and rest of the brain regions. Norepinephrine was significantly increased in almost all the regions except for rest of the brain region where a significant decrease was noticed. A reduction in spontaneous locomotor activity and learning ability was also observed. Cessation of the Cd‐treatment for 30 days could not reverse the alterations in the neurotransmitter levels induced by the previous treatment except for the levels of 5‐hydroxytryptamine in cerebellum and norepinephrine levels in the cerebral cortex and hippocampus. The behavioral deficits also persisted suggesting a long lasting neurological effects of cadmium exposure.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
