Abstract
We and others have previously described neuroaxonal dystrophic changes as one of the hallmarks of structural diabetic autonomic polyneuropathy involving sympathetic nerves. In the present study, a systemic search for similar changes was undertaken in the mainly sensory symmetric polyneuropathy of the spontaneously diabetic BB-rat. Changes identical to those described in sympathetic nerves in this model were found in sensory ganglion cells, in their proximal extramedullary axons, and in proximal and distal myelinated axons of the spinal dorsal columns. The dystrophic substructures consisted of tubulovesicles, tubular rings, layered membranes, electron-dense membranous bodies, and neurofilamentous changes. Neuroaxonal dystrophic abnormalities increased with increasing duration of diabetes, and exhibited a topographic distribution along the sensory neuroaxonal axis, suggesting metabolic abnormalities as well as abnormalities in the turn-around mechanism of fast axonal transport in the pathogenesis of dystrophic changes in diabetic nerves.
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