Neuroanatomical and Neurochemical Substrates of Drug-Seeking Behavior: Overview and Future Directions

Abstract

The focus of this volume, Molecular and Cellular Aspects of the Drug Addictions, addresses but one perspective of an admittedly complex biological, psychological, and social phenomenon: the administration of drugs for nonmedical reasons. It is readily acknowledged that, in the human, “drug abuse” and “addiction” involve interactions between biological, psychological, and social dimensions. However, it is also readily apparent from both human and animal research that much can be discussed concerning the biological dimension; drugs are self-administered because of their effects on biological systems in the brain. Moreover, research is leading us steadily closer to the specific neurochemical, neuroanatomical, molecular, and cellular actions that are important in the self-administration of drugs.