Abstract
Neuro-Oncology During the COVID-19 Outbreak: A Hopeful Perspective at the End of the Italian Crisis.
Highlights
Cancer patients are more susceptible to infections because of their immunosuppressive status and, at least in theory, at major risk of developing severe complications from the coronavirus disease (COVID-19), including adult respiratory distress syndrome (ARDS), intensive care unit admission, and even death
Patients diagnosed with primary brain tumors (PBTs) are considered one of the most fragile and vulnerable category due to several factors: the older age along with the multiple age-related frailties and comorbidities, the frequent presence of neurological deficits causing loss of autonomy in the activities of daily living and increased risk of thromboembolic events, the often severe lymphopenia both disease and treatment-related, and the chronic use of steroids to control brain edema leading to further immunosuppression and to an increased susceptibility to infection [8]
Another pathogenic mechanism under current investigation potentially leading to neurological damages in patients with COVID-19 is represented by endothelial ruptures in cerebral capillaries followed by bleeding within the brain parenchyma [12]
Summary
Cancer patients are more susceptible to infections because of their immunosuppressive status and, at least in theory, at major risk of developing severe complications from the coronavirus disease (COVID-19), including adult respiratory distress syndrome (ARDS), intensive care unit admission, and even death. More recent works indicated with strong evidence that cancer patients are at an increased risk of mortality and severe illness due to SARS-CoV-2 infection, regardless of whether they have active cancer, are on anticancer treatment, or both [5, 6].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
