Abstract
The neuroendocrine tumor of extrahepatic biliary tract is a rare neoplasm of the gastrointestinal tract. We present a case of 16 year old male presenting with epigastric pain and jaundice with a well-defined lesion in common hepatic duct on imaging. The patient underwent tumor resection. Histopathology examination revealed thickened common hepatic duct infiltrated by tumor cells with expression of Pan CK, Synaptophysin & Chromogranin with Ki- 67 proliferation index of 5%. The final diagnosis of Neuroendocrine tumor of Common Hepatic Duct, grade 2 was rendered. The patient showed no recurrence to date without intravenous chemotherapy.
Highlights
Case ReportThe neuroendocrine tumor of extrahepatic biliary tract is a rare neoplasm of the gastrointestinal tract
Neuroendocrine tumor of a biliary tract is a rare malignant tumor of gastrointestinal neuroendocrine tumors constituting about 0.2 – 2 percent.[1,2] The tumor most commonly arises from a common bile duct followed by hilar confluence, cystic duct, common hepatic duct and left hepatic duct
Gastrointestinal tract is a large neuroendocrine system, the distribution of neuroendocrine cells is not uniform with most of the neuroendocrine tumor occurring in the gut while extrahepatic biliary tract has least number of neuroendocrine cells leading to rare occurrence of neuroendocrine tumor in extrahepatic biliary tract, to best of our knowledge less than 80 cases have been reported in literature
Summary
The neuroendocrine tumor of extrahepatic biliary tract is a rare neoplasm of the gastrointestinal tract. We present a case of 16 year old male presenting with epigastric pain and jaundice with a well-defined lesion in common hepatic duct on imaging. Histopathology examination revealed thickened common hepatic duct infiltrated by tumor cells with expression of Pan CK, Synaptophysin & Chromogranin with Ki- 67 proliferation index of 5%. The final diagnosis of Neuroendocrine tumor of Common Hepatic Duct, grade 2 was rendered. The patient showed no recurrence to date without intravenous chemotherapy.
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