Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations

Hao Li,Shen-Ju Chou,Tadashi Hamasaki,Dennis Dm O'Leary,Carlos G Perez-Garcia

doi:10.1186/preaccept-5399422785587359

Abstract

Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations

Highlights

Cortical GABAergic interneurons (INs) are generated in the medial ganglionic eminence (MGE) and migrate tangentially into cortex
Distributions of ErbB4-expressing interneurons migrating from MGE to cortex show minimum overlap with expression domains of Nrg1 isoforms and Nrg3 Most cortical GABAergic INs originating from the MGE express the receptor tyrosine kinase ErbB4 [29], which binds NRGs and activates their signaling pathways
Complementary patterns in distribution of MGE-derived interneurons and NRG expression domains are degraded in mice deficient for NRG-ErbB4 signaling In WT mice, we find that as ErbB4-expressing, GABAergic INs migrate from the MGE to cortex, they take paths that have low or undetectable levels of NRG expression and tend to avoid the surrounding domains of NRG expression (Figures 1, 2, 3, and 4)

Summary

Introduction

Cortical GABAergic interneurons (INs) are generated in the medial ganglionic eminence (MGE) and migrate tangentially into cortex. The MGE and CGE give rise to most of the GABAergic INs that migrate tangentially into dTel, including neocortex and hippocampus [2,3,4,5,6,7]. MGE-derived GABAergic INs migrate through the cortex within the marginal zone (MZ) and the interface between the intermediate zone (IZ) and the subventricular zone (SVZ). After these INs reach their appropriate cortical location, they migrate to their final cortical layer by using either multimodal migration [8] or radial migration perpendicular to their original tangential paths in the MZ and IZ [9]

Methods

Results

Conclusion