Abstract
Various external factors modulate the metabolic efficiency of mitochondria. This review focuses on the impact of the growth factor neuregulin and its ErbB receptors on mitochondria and their relationship with several physiopathological alterations. Neuregulin is involved in the differentiation of heart, skeletal muscle, and the neuronal system, among others; and its deficiency is deleterious for the health. Information gathered over the last two decades suggests that neuregulin plays a key role in regulating the mitochondrial oxidative machinery, which sustains cell survival and insulin sensitivity.
Highlights
Reviewed by: Douglas Sawyer, Maine Medical Center, Maine Health, United States Charles Affourtit, University of Plymouth, United Kingdom
This review focuses on the impact of the growth factor neuregulin and its ErbB receptors on mitochondria and their relationship with several physiopathological alterations
Neuregulin is involved in the differentiation of heart, skeletal muscle, and the neuronal system, among others; and its deficiency is deleterious for the health
Summary
Reviewed by: Douglas Sawyer, Maine Medical Center, Maine Health, United States Charles Affourtit, University of Plymouth, United Kingdom. The observation that NRG prevents the deleterious effects of oxidative stress is supported by previous reports indicating that the release of this growth factor by cardiac endothelial cells prevents cardiomyocyte apoptosis by regulating ROS levels, in a manner that involves ErbB4 activation (Kuramochi et al, 2004).
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