Abstract
This study aimed to identify a new biological activity of the widely distributed species Fagopyrum dibotrys. Four F. dibotrys extracts (ethyl acetate (EA), petroleum ether (P), ethanol (E), and water (W)) were explored for their anti-neuraminidase (NA) activity. A total of 32 compounds were identified using UHPLC-Q-Exactive Orbitrap HRMS in the EA extract, which had the best NA inhibitory effects. We used the docking data for supporting compounds’ anti-neuraminidase activity. Among them, five compounds including one flavonoid, three organic acids, and one glucoside were discovered for the first time in F. dibotrys. Docking studies and NA activity assay revealed the remarkable NA inhibitory activity of eight components in EA extract, especially rutin, hesperidin, procyanidin B2, and quercitrin. Therefore, F. dibotrys could be used to develop anti-influenza drugs.
Highlights
Fagopyrum dibotrys is an important crude drug and functional food that has been widely used in traditional Chinese medicine (TCM) [1]
The Q-Exactive system with the its high resolving power performance combines with ultra-high performance liquid chromatography (UHPLC)
We demonstrated for the first time that F. dibotrys can cause certain NA inhibitory effects from three aspects
Summary
Fagopyrum dibotrys is an important crude drug and functional food that has been widely used in traditional Chinese medicine (TCM) [1]. It mainly grows in China, Vietnam, India, and Thailand [2]. The herb, which has been recorded in the Chinese Pharmacopoeia since 1977, is a functional food and has been approved by National Health and Family Planning Commission of the People’s Republic of China (NHFPC) It called Fagopyrum cumosum (Trev.) Meisn, whose rhizome was considered as folk medicine for clearing away heat and toxic materials, expelling pus and removing blood stasis [3,4,5]. Molecular docking is a reliable and efficient tool for discovering or designing novel drugs used to screen biological chemical compounds [10,11,12,13]
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