Neural responses to negative feedback are related to negative emotionality in healthy adults

Abstract

Prior neuroimaging and electrophysiological evidence suggests that potentiated responses in the anterior cingulate cortex (ACC), particularly the rostral ACC, may contribute to abnormal responses to negative feedback in individuals with elevated negative affect and depressive symptoms. The feedback-related negativity (FRN) represents an electrophysiological index of ACC-related activation in response to performance feedback. The purpose of the present study was to examine the FRN and underlying ACC activation using low resolution electromagnetic tomography source estimation techniques in relation to negative emotionality (a composite index including negative affect and subclinical depressive symptoms). To this end, 29 healthy adults performed a monetary incentive delay task while 128-channel event-related potentials were recorded. We found that enhanced FRNs and increased rostral ACC activation in response to negative--but not positive--feedback was related to greater negative emotionality. These results indicate that individual differences in negative emotionality--a putative risk factor for emotional disorders--modulate ACC-related processes critically implicated in assessing the motivational impact and/or salience of environmental feedback.