Abstract

ObjectiveThis study aims to investigate the effect of rosuvastatin on sympathetic neural remodeling of the left atrium (LA) in rats after myocardial infarction (MI).MethodsRats were randomly divided into a three groups: sham group, statin group, and MI group. The mRNA expression levels of the growth-associated protein-43 (GAP43) and nerve growth factor (NGF) were measured by RT-PCR. Immunohistochemistry was used to detect the distribution and density of GAP43- and NGF-positive nerves. The expression levels of these proteins were quantified by Western blot.ResultsCompared with the sham group, the average optical density (AOD) values of GAP43 and nerve growth factor (NGF)-positive substances in the LA in the statin and MI groups were significantly higher (P<0.01), but the AOD values in the statin group were lower than of those in the MI group (P<0.01). Furthermore, the AOD values of GAP43 and NGF positive nerves in the left stellate ganglion in the statin and MI groups were significantly higher (P<0.01), but the AOD values in the statin group were lower, when compared with the MI group (P<0.01).ConclusionRosuvastatin could effectively improve the sympathetic neural remodeling of LA in MI rats.

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