Abstract
Recent advances from both preclinical and clinical studies have lead to a molecular and cellular hypothesis of depression. Preclinical studies demonstrate that stress decreases the survival, size, and neurogenesis of neurons in the hippocampus. In addition, clinical imaging studies demonstrate that the volume of the hippocampus is significantly reduced in depressed patients. Regulation of neuronal survival and size are likely to involve multiple mechanisms, including regulation of neurotrophic factors.
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